Publications

(Link to Pubmed MyBibliography Here)

Schmidt Lab Publications

Aranda ML, Bhoi JD, Payan-Parra OA, Lee SK, Yamada T, Yang Y, Schmidt TM (2025) Genetic tuning of intrinsically photosensitive retinal ganglion cell subtype identity to drive visual behavior. Nature Communications. 2025 Sep 30;16:8678.
Vlasits AL, Syeda M, Wickman A, Guzman P, Schmidt TM (2025) Atypical retinal function in a mouse model of Fragile X syndrome. J Neurosci. 2 July 2025, 45 (27) e0013252025
Calanni JS, Aranda ML, Dieguez HH, Dorfman D, Schmidt TM, Rosenstein RE. (2024) An ethologically relevant paradigm to assess defensive response to visual contrast stimuli. Sci Rep. 2024 May 31;14:12499.
Lucas RJ, Allen AE, Brainard GC, Brown TM, Dauchy RT, Didikoglu A, Do MTH, Gaskill BN, Hattar S, Hawkins P, Hut RA, McDowell RJ, Nelson RJ, Prins J-B, Schmidt TM, Takahashi JS, Verma V, Vöikar V, Wells S, Peirson SN (2024) Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research. PLOS Biology.
Mahoney HM, Schmidt TM (2024) Visual circuits impacting cognition. Nature Reviews Neuroscience. 2024 Mar;25(3):159-175.
Contreras EC, Bhoi J, Sonoda T, Birnbaumer L, Schmidt TM (2023) Melanopsin activates divergent phototransduction pathways in ipRGC subtypes. eLife.
Caval-Holme FS, Aranda ML, Chen AQ, Tiriac A, Zhang Y, Smith B, Birnbaumer L, Schmidt TM, Feller MB. The retinal basis of light aversion in neonatal mice (2022). J Neurosci. 18 May 2022, 42 (20) 4101-4115
Contreras EC*, Nobleman AP*, Robinson P#, Schmidt TM# (2021). Melanopsin phototransduction: Beyond canonical cascades. Journal of Experimental Biology. 224(23)jeb226522.
Aranda ML, Schmidt TM (2021) Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions. Cellular and Molecular Life Sciences. 78(3):889-907.
Sonoda T, Li JY, Hayes NW, Chan JC, Okabe Y, Belin S, Nawabi H, Schmidt TM (2020) A non-canonical inhibitory circuit dampens behavioral sensitivity to light. Science. 368:527-531.
- *Previewed in: Ding J, Wei W (2020) Dampening Light Sensitivity. Science. 368:417-472.
Sonoda T, Okabe Y, Schmidt TM (2020) Overlapping morphological and functional properties between M4 and M5 intrinsically photosensitive retinal ganglion cells. Journal of Comparative Neurology. 528:1028-1040.
Lee SK, Sonoda T, Schmidt TM (2019) M1 ipRGCs integrate rod and melanopsin inputs to signal in low light. Cell Reports. 29 3349-3355.
Lucas JA and Schmidt TM (2019). Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development. Neural Development. 14(1):8.
Rupp AC, Ren M, Altimus C, Fernandez D, Richardson M, Turek F, Hattar S, Schmidt TM. (2019) Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep. eLife 8:e44358.
Bray ER, Yungher BJ, Levay K, Ribeiro M, Dvoryanchikov G, Ayupe AC, Thakor K, Marks V, Randolph M, Danzi MC, Schmidt TM, Chaudhari N, Lemmon VP, Hattar S, Park KK (2019) Thrombospondin-1 mediates axon regeneration in retinal ganglion cells. Neuron. ePub June 18, 2019. doi: 10.1016/j.neuron.2019.05.044.
Munteanu T, Noronha K, Leung AC, Pan S, Lucas JA, Schmidt TM (2018) Light-dependent pathways for dopaminergic amacrine cell development and function. eLife 7:e39866.
Sonoda T, Lee SK, Birnbaumer L, Schmidt TM (2018) Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits. Neuron 99(4):754-767.
- Previewed in: Pottackal J and Demb JB (2018) Melanopsin shows its (contrast-)sensitive side. Neuron 99(4):630-632.
Li JY and Schmidt TM (2018) Divergent projection patterns of M1 ipRGC subtypes. J Comp Neurol 526(13):2010-2018.
Tufford AR, Onyak JR, Sondereker KB, Lucas JA, Earley AM, Mattar P, Hattar S, Schmidt TM, Renna JM, Cayouette M. (2018) Melanopsin retinal ganglion cells regulate cone photoreceptor lamination in the mouse retina. Cell Reports 23(8):2416-2428.
Lee SK and Schmidt TM (2018) Morphological identification of melanopsin-expressing ganglion cell subtypes in mice. In: Tanimoto N. (eds) Mouse Retinal Phenotyping, Methods in Molecular Biology, vol 1753. Humana Press, New York, NY.
Laboissonniere LA, Sonoda T, Lee SK, Trimarchi JM, Schmidt TM (2017) Single-cell RNA-seq of defined subsets of retinal ganglion cells. J Vis Exp (123), e55229.
Sonoda T, Schmidt TM (2016) Reevaluating the role of intrinsically photosensitive retinal ganglion cells: New roles in image forming functions. Integrative and Comparative Biology 56(5):834-841.
Sonoda T, Lee SK (2016) A novel role for the visual retinoid cycle in melanopsin chromophore regeneration. J Neurosci 36(35):9016-9018.
Berkowitz BA, Schmidt TM, Podolsky RH, Roberts R (2016) Melanopsin phototransduction contributes to light-evoked choroidal expansion in mice. Invest Ophthalmol Vis Sci 57(13):5314-5319
Schmidt Lab Preprints
Rupp AC, Ren M, Altimus C, Fernandez D, Richardson M, Turek F, Hattar S, Schmidt TM. Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep. BioRxiv 496323 [Preprint]. December 13, 2018. Available from https://doi.org/10.1101/496323.
Lucas JA and Schmidt TM. Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development. BioRxiv 619387 [Preprint]. April 26, 2019. Available from https://doi.org/10.1101/619387.

Previous Publications from Tiffany Schmidt

Schmidt TM, Alam NM, Chen S, Kofuji P, Li W, Prusky GT, Hattar S (2014) Role for melanopsin in alpha retinal ganglion cells and contrast detection. Neuron 82(4): 781-788.
Chew KS, Schmidt TM, Rupp AC, Kofuji P, Trimarchi JM (2014) Loss of Gq/11 genes does not abolish melanopsin phototransduction. PLOS ONE 9(5): e98356.
Sand AM, Schmidt TM, Kofuji P (2012) Diverse types of ganglion cell photoreceptors in the mammalian retina. Progress in Retinal and Eye Research 31(4): 287-302.
Schmidt TM, Chen S-K, Hattar S (2011) Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions. Trends Neurosci 34 (11): 572-580.
Schmidt TM and Kofuji P (2011) An isolated retinal preparation to record light responses from genetically labeled retinal ganglion cells. J Vis Exp 47.
Perez-Leighton CE*, Schmidt TM*, Abramovitz J, Birnbaumer L, Kofuji P (2011) Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC channel subunits. Eur J Neurosci 33(5):856-867.
Schmidt TM and Kofuji P (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 519(8): 1492-1504.
Schmidt TM, Do MT, Dacey DM, Lucas R, Hattar S, Matynia A (2011) Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function. J Neurosci 31(45): 16094-101
Tang X, Schmidt TM, Perez-Leighton CE, Kofuji P (2010) Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glia cells in sensory ganglia. Neuroscience 166(2): 397-407.
Schmidt TM and Kofuji P (2010) Differential cone pathway influence on intrinsically photosensitive retinal ganglion cell subtypes. J Neurosci 30 (48): 16262-16271.
Bishop DI, Meyer BC, Schmidt TM, and Gray BR (2009) Differential investment behavior between grandparents and grandchildren: the role of paternity uncertainty. Evolutionary Psychology 7(1): 66-77.
Schmidt TM and Kofuji P (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci 29(2): 476-482.
Schmidt TM (2009) Role of melastatin-related transient receptor potential channel TRPM1 in the retina: clues taken from horses and mice. J Neurosci 29(38): 11720-11722.
Schmidt TM, Taniguchi K, and Kofuji P (2008) Intrinsic and extrinsic light responses in melanopsin-expressing ganglion cells during mouse development. J Neurophysiol 100:371-384.
Schmidt TM and Kofuji P (2008) Novel insights into non-image forming visual processing in the retina. Cellscience 5(1): 77-83.